Bousquet Philippe J, Cropet Claire, Klossek Jean Michel, Allaf Bachar, Neukirch Françoise, Bousquet Jean
University Hospital and INSERM U780, Montpellier, France.
Ann Allergy Asthma Immunol. 2009 Sep;103(3):195-200. doi: 10.1016/S1081-1206(10)60181-0.
Tobacco smoking is common in patients with allergic rhinitis.
To examine the impact of smoking on allergic rhinitis.
Two cross-sectional studies (performed between March 1, 2002, and February 28, 2003) assessed the impact of tobacco smoking on the symptoms and quality of life of untreated patients with diagnosed allergic rhinitis who had consulted with primary care physicians (472 patients) and specialists (672 patients). Both studies used the same methods and were combined. Rhinitis was classified according to the Allergic Rhinitis and its Impact on Asthma initiative. The European Community Respiratory Health Survey questionnaire on smoking and the disease-specific Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) were used.
A total of 20.8% of the patients were smokers and 10.9% were ex-smokers. More than 78% of the patients had moderate to severe symptoms of rhinitis. Fewer patients had moderate to severe nasal pruritus or loss of smell. There appeared to be no significant difference in the severity of nasal symptoms, depending on the smoking status. Moderate to severe nasal obstruction was observed in 78.8% of the nonsmokers, 79.0% of the smokers, and 77.4% of the ex-smokers. Overall and individual domain scores in the RQLQ were not altered by the smoking status. The overall median (25th-75th percentiles) RQLQ score was 2.8 (2.1-3.5) in nonsmokers, 2.7 (2.0-3.5) in smokers, and 2.7 (1.9-3.5) in ex-smokers.
In the present study, which was performed with a large number of untreated patients with a diagnosis of allergic rhinitis, smoking was found not to alter nasal symptoms or nasal-specific quality of life.
吸烟在过敏性鼻炎患者中很常见。
研究吸烟对过敏性鼻炎的影响。
两项横断面研究（于2002年3月1日至2003年2月28日进行）评估了吸烟对已确诊过敏性鼻炎且未接受治疗的患者症状及生活质量的影响，这些患者咨询过初级保健医生（472例）和专科医生（672例）。两项研究采用相同方法并合并分析。鼻炎根据“变应性鼻炎及其对哮喘的影响”计划进行分类。使用了欧洲共同体呼吸健康调查中关于吸烟的问卷以及特定疾病的鼻结膜炎生活质量问卷（RQLQ）。
共有20.8%的患者为吸烟者，10.9%为既往吸烟者。超过78%的患者有中度至重度鼻炎症状。有中度至重度鼻痒或嗅觉丧失的患者较少。根据吸烟状况，鼻症状的严重程度似乎没有显著差异。78.8%的非吸烟者、79.0%的吸烟者和77.4%的既往吸烟者有中度至重度鼻塞。RQLQ的总体及各领域得分未因吸烟状况而改变。非吸烟者的RQLQ总体中位数（第25至75百分位数）得分为2.8（2.1 - 3.5），吸烟者为2.7（2.0 - 3.5），既往吸烟者为2.7（1.9 - 3.5）。
在本研究中，对大量已确诊未治疗的过敏性鼻炎患者进行研究发现，吸烟并未改变鼻症状或鼻部特定的生活质量。
