Huo Fang-Jun, Sun Yuan-Qiang, Su Jing, Chao Jian-Bin, Zhi Hai-Juan, Yin Cai-Xia
Research Institute of Applied Chemistry, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, 030006, China.
Org Lett. 2009 Nov 5;11(21):4918-21. doi: 10.1021/ol901951h.
A new thiol-containing colorimetric probe has been developed by using a chromene derivative, 7-nitro-2,3-dihydro-1H-cyclopenta[b]chromen-1-one (1). The molecule exhibited high selectivity and sensitivity for detecting thiol species as cysteine, homocysteine, and glutathione in aqueous solution through a rapid visual color change from colorless to yellow.
通过使用一种色烯衍生物7-硝基-2,3-二氢-1H-环戊并[b]色烯-1-酮（1），开发了一种新型含硫醇比色探针。该分子通过从无色到黄色的快速视觉颜色变化，对水溶液中的半胱氨酸、高半胱氨酸和谷胱甘肽等硫醇类物质表现出高选择性和高灵敏度。
