Mahdi Abbas Ali, Shukla Kamla Kant, Ahmad Mohammad Kaleem, Rajender Singh, Shankhwar Satya Narain, Singh Vishwajeet, Dalela Deepansh
Medical Elementology and Free Radical Biology Lab, Department of Biochemistry, C.S.M. Medical University, (Formerly King George's Medical University), Lucknow 226003, India.
Evid Based Complement Alternat Med. 2009 Sep 29;2011. doi: 10.1093/ecam/nep138.
Stress has been reported to be a causative factor for male infertility. Withania somnifera has been documented in Ayurveda and Unani medicine system for its stress-combating properties. However, limited scientific literature is available on this aspect of W. somnifera. We undertook the present study to understand the role of stress in male infertility, and to test the ability of W. somnifera to combat stress and treat male infertility. We selected normozoospermic but infertile individuals (N = 60), further categorized in three groups: normozoospermic heavy smokers (N = 20), normozoospermics under psychological stress (N = 20) and normozoospermics with infertility of unknown etiology (N = 20). Normozoospermic fertile men (N = 60) were recruited as controls. The subjects were given root powder of W. somnifera at a rate of 5 g/day for 3 months. Measuring various biochemical and stress parameters before and after treatment, suggested a definite role of stress in male infertility and the ability of W. somnifera to treat stress-related infertility. Treatment resulted in a decrease in stress, improved the level of anti-oxidants and improved overall semen quality in a significant number of individuals. The treatment resulted in pregnancy in the partners of 14% of the patients.
据报道，压力是男性不育的一个致病因素。印度人参在阿育吠陀和尤那尼医学体系中因其抗压特性而有记载。然而，关于印度人参这方面的科学文献有限。我们开展了本研究，以了解压力在男性不育中的作用，并测试印度人参对抗压力和治疗男性不育的能力。我们选择了精子正常但不育的个体（N = 60），进一步分为三组：精子正常的重度吸烟者（N = 20）、处于心理压力下的精子正常者（N = 20）和病因不明的不育精子正常者（N = 20）。招募精子正常的 fertile 男性（N = 60）作为对照。受试者每天服用5克印度人参根粉，持续3个月。在治疗前后测量各种生化和压力参数，表明压力在男性不育中具有明确作用，且印度人参具有治疗与压力相关不育的能力。治疗导致压力降低，抗氧化剂水平提高，并且在相当数量的个体中改善了整体精液质量。治疗使14%的患者的伴侣怀孕。
