Faculty of Physical Activity Sport Sciences, European University of Madrid, 28670, Madrid, Spain.
Departamento de Biología Celular, Genética, Histología y Farmacología, Facultad de Ciencias de la Salud, Campus de Soria, Universidad de Valladolid, Soria, 42004, Spain.
Curr Nutr Rep. 2023 Sep;12(3):465-477. doi: 10.1007/s13668-023-00481-0. Epub 2023 Jul 10.
Withania somnifera (L.) Dunal (Ws) is a common herb plant that has been used for centuries to treat a wide range of conditions, particularly certain chronic diseases due to its antidiabetic, cardioprotective, antistress, and chondroprotective effects, among many others. No conclusive evidence, however, exists about the potential health effects of Ws in adults without chronic conditions. We aimed to evaluate the current evidence on the health benefits of Ws supplementation in healthy adults. RECENT FINDINGS: Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically reviewed studies indexed in Web of Science, Scopus, and PubMed to assess the effects of Ws on hematological and biochemical markers, hormonal behavior, and oxidant response in healthy adults. Original articles published up to March 5, 2022, with a controlled trial design or pre-post intervention design, in which supplementation of Ws was compared to a control group or data prior to intervention were included. Among 2,421 records identified in the search, 10 studies met the inclusion criteria. Overall, most of the studies reported beneficial effects of the Ws supplementation, and no serious adverse events were reported. Participants supplemented with Ws displayed reduced levels of oxidative stress and inflammation, and counterbalanced hormone levels. No evidence of the beneficial effects of Ws supplementation on hematological markers was reported. Ws supplementation appears to be safe, may regulate hormone levels, and has potent anti-inflammatory and antioxidant effects. However, further studies are needed to elucidate the relevance of its application.
睡茄（Ws）是一种常见的草本植物，几个世纪以来一直被用于治疗多种疾病，特别是某些慢性疾病，因为它具有降血糖、心脏保护、抗应激和软骨保护等作用。然而，对于没有慢性疾病的成年人，Ws 是否对健康有潜在影响，目前尚无确凿的证据。我们旨在评估 Ws 补充剂对健康成年人健康益处的现有证据。
根据系统评价和荟萃分析的首选报告项目（PRISMA）指南，我们系统地检索了 Web of Science、Scopus 和 PubMed 中索引的研究，以评估 Ws 对健康成年人血液学和生化标志物、激素行为和氧化应激反应的影响。纳入的原始文章为试验设计或前后干预设计的对照试验，其中 Ws 补充剂与对照组或干预前的数据进行了比较，发表时间截至 2022 年 3 月 5 日。
在搜索中确定的 2421 条记录中，有 10 项研究符合纳入标准。总的来说，大多数研究报告了 Ws 补充的有益效果，且没有严重的不良事件报告。补充 Ws 的参与者表现出氧化应激和炎症水平降低，以及激素水平得到平衡。没有证据表明 Ws 补充剂对血液学标志物有有益的影响。
Ws 补充剂似乎是安全的，可能调节激素水平，具有强大的抗炎和抗氧化作用。然而，需要进一步的研究来阐明其应用的相关性。
