Faculty of Medicine, Norwegian University of Science and Technology, and Department of Pulmonary Medicine, St. Olav University Hospital, Trondheim, Norway.
Scand J Med Sci Sports. 2010 Feb;20(1):e170-6. doi: 10.1111/j.1600-0838.2009.00937.x. Epub 2009 May 26.
High-intensity work might not be preserved in chronic obstructive pulmonary disease (COPD) during whole-body exercise due to ventilatory limitations that exceed metabolic limitations, resulting in reduced training adaptations. The purpose of the present study was to address the hyperoxic effect during training and testing in COPD patients with hypoxemia at peak exercise. Six COPD and eight coronary artery disease (CAD) patients completed 24 aerobic high-intensity interval training sessions, 4x4 min in hyperoxia at 85-95% of the peak heart rate and peak exercise tested in normoxia and hyperoxia pre- and post-training. VO2peak increased in the COPD group by 19% (13-31%) and in the CAD group by 15% (7-29%), [0.98(0.68-1.52)-1.17(0.89-1.78) and 2.11(1.57-2.64)-2.44(1.92-3.39) L/min], respectively. VO2peak was higher in hyperoxia at pre- and post-test (1.22(0.80-1.87) and 1.37(1.01-1.94) L/min) in the COPD group. Work economy improved by 10% in both groups. Quality of life improved in the COPD group in terms of physical and mental health status by 24% and 35%. Hyperoxic aerobic high-intensity interval training in COPD patients with hypoxemia at peak exercise increases VO2peak, peak workload, work economy and quality of life. Acute hyperoxia increases VO2peak, peak workload at pre- and post-test compared with normoxia in the COPD patients, indicating an oxygen supply limitation to VO2peak.
高强度工作可能不会在 COPD 患者的全身运动中得到保留，因为通气限制超过代谢限制，导致训练适应减少。本研究的目的是探讨 COPD 患者在运动峰值时存在低氧血症的情况下，训练和测试中的高氧效应。6 名 COPD 患者和 8 名冠心病（CAD）患者完成了 24 次有氧高强度间歇训练，4x4 分钟在高氧（85-95%的峰值心率和峰值运动）中，在训练前后的常氧和高氧中进行测试。COPD 组的峰值摄氧量增加了 19%（13-31%），CAD 组增加了 15%（7-29%），[0.98（0.68-1.52）-1.17（0.89-1.78）和 2.11（1.57-2.64）-2.44（1.92-3.39）L/min]，分别。COPD 组在测试前和测试后的高氧环境中，峰值摄氧量更高（1.22（0.80-1.87）和 1.37（1.01-1.94）L/min）。两组的工作经济性均提高了 10%。COPD 组的生活质量在身体和精神健康状况方面分别提高了 24%和 35%。在 COPD 患者中，在运动峰值时存在低氧血症的情况下进行高氧有氧高强度间歇训练可以增加峰值摄氧量、峰值工作量、工作经济性和生活质量。急性高氧增加了 COPD 患者测试前和测试后的峰值摄氧量和峰值工作量，表明峰值摄氧量存在氧气供应限制。
