Eck H P, Betzler M, Schlag P, Dröge W
Institute of Immunology and Genetics, German Cancer Research Center, Heidelberg.
J Cancer Res Clin Oncol. 1990;116(6):648-50. doi: 10.1007/BF01637088.
Glutamate was recently found to inhibit the membrane transport of cystine and to impair the function of macrophages and lymphocytes in vitro. Elevated plasma glutamate concentrations in patients with advanced carcinoma were also found to be quantitatively correlated with reduced lymphocyte reactivity in these persons. We now investigated the questions whether glutamate levels in tumor patients would decline to approximately normal levels after tumor resection and, if so, whether this would be correlated with a recovery of lymphocyte reactivity. We report that plasma glutamate levels as well as the concomitantly elevated plasma lactate levels of patients with colorectal carcinoma return to practically normal levels within 1 week after curative surgery. This is accompanied by a rapid recovery of the lymphocyte reactivity against concanavalin A. Lymphocyte responses against pokeweed mitogen and phytohemagglutinin, in contrast, remain impaired for at least 6 months, indicating that elevated glutamate levels in patients with colorectal carcinoma are associated with a long-lasting defect in the immune system.
最近发现谷氨酸能抑制胱氨酸的膜转运，并在体外损害巨噬细胞和淋巴细胞的功能。还发现晚期癌症患者血浆谷氨酸浓度升高与这些患者淋巴细胞反应性降低在数量上相关。我们现在研究了肿瘤患者的谷氨酸水平在肿瘤切除后是否会降至大致正常水平的问题，如果是这样，这是否与淋巴细胞反应性的恢复相关。我们报告，结直肠癌患者的血浆谷氨酸水平以及同时升高的血浆乳酸水平在根治性手术后1周内实际上恢复到正常水平。这伴随着淋巴细胞对伴刀豆球蛋白A反应性的迅速恢复。相比之下，淋巴细胞对商陆有丝分裂原和植物血凝素的反应至少6个月仍受损，这表明结直肠癌患者谷氨酸水平升高与免疫系统的长期缺陷有关。
