Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Clin Exp Immunol. 2009 Dec;158(3):272-80. doi: 10.1111/j.1365-2249.2009.04033.x. Epub 2009 Sep 30.
Since their discovery more than 15 years ago, the mitogen activated protein kinases (MAPK) have been implicated in an ever-increasingly diverse array of pathways, including inflammatory signalling cascades. Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are characterized by the perpetual production of inflammatory mediators. Research into the transduction pathway behind this over-production has highlighted the potential mediating role for the MAPKs and their related signalling components. This review highlights some of the research into the role for the MAPKs and their related signalling proteins in influencing the progression of IBD.
自 15 多年前被发现以来，丝裂原活化蛋白激酶 (MAPK) 已经涉及到越来越多的不同途径，包括炎症信号级联。炎症性肠病（IBD），如溃疡性结肠炎和克罗恩病，其特征是持续产生炎症介质。对这种过度产生背后的转导途径的研究强调了 MAPKs 及其相关信号成分的潜在介导作用。本文综述了 MAPKs 及其相关信号蛋白在影响 IBD 进展中的作用的一些研究。
