MRC Human Reproductive Sciences Unit Reproductive and Developmental Sciences, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
Reproduction. 2009 Dec;138(6):903-19. doi: 10.1530/REP-09-0247. Epub 2009 Sep 30.
Inflammation involves alterations to vascular and immune cell function. It is well recognised that many physiological reproductive events such as ovulation, menstruation, implantation and onset of labour display hallmark signs of inflammation. These are orchestrated by specific molecular pathways involving a host of growth factors, cytokines, chemokines and lipid mediators. Resumption of normal reproductive function involves prompt and proper resolution of these inflammatory pathways. Recent literature confirms that resolution of inflammatory pathways involves specific biochemical events that are activated to re-establish homeostasis in the affected tissue. Moreover, initiation and maintenance of inflammatory pathways are the key components of many pathologies of the reproductive tract and elsewhere in the body. The onset of reproductive disorders or disease may be the result of exacerbated activation and maintenance of inflammatory pathways or their dysregulated resolution. This review will address the role of inflammatory events in normal reproductive function and its pathologies.
炎症涉及血管和免疫细胞功能的改变。人们已经认识到，许多生理生殖事件，如排卵、月经、着床和分娩，都表现出炎症的标志性特征。这些特征是由特定的分子途径协调的，涉及一系列生长因子、细胞因子、趋化因子和脂质介质。恢复正常的生殖功能需要这些炎症途径的迅速和适当的解决。最近的文献证实，炎症途径的解决涉及到特定的生化事件，这些事件被激活以在受影响的组织中重新建立体内平衡。此外，炎症途径的启动和维持是生殖系统和身体其他部位许多疾病的关键组成部分。生殖障碍或疾病的发生可能是由于炎症途径的过度激活和维持，或其失调的解决。这篇综述将探讨炎症事件在正常生殖功能及其病理学中的作用。
