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侧流技术与半乳甘露聚糖及（1->3）-β-D-葡聚糖检测法在侵袭性肺曲霉病检测中的比较

Comparison of lateral flow technology and galactomannan and (1->3)-beta-D-glucan assays for detection of invasive pulmonary aspergillosis.

作者信息

Wiederhold Nathan P, Thornton Christopher R, Najvar Laura K, Kirkpatrick William R, Bocanegra Rosie, Patterson Thomas F

机构信息

University of Texas at Austin College of Pharmacy, Austin, Texas, USA.

出版信息

Clin Vaccine Immunol. 2009 Dec;16(12):1844-6. doi: 10.1128/CVI.00268-09. Epub 2009 Sep 30.

DOI:10.1128/CVI.00268-09
PMID:19793899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2786380/
Abstract

We compared a lateral flow device to galactomannan and (1-->3)-beta-D-glucan assays to detect invasive aspergillosis in an established guinea pig model of pulmonary disease. The lateral flow device became positive earlier (day 3) than the (1-->3)-beta-D-glucan and galactomannan assays (day 5), with all samples positive by each assay on day 7.

摘要

我们在已建立的豚鼠肺部疾病模型中，将一种侧向流动装置与半乳甘露聚糖和（1→3）-β-D-葡聚糖检测法进行比较，以检测侵袭性曲霉病。侧向流动装置比（1→3）-β-D-葡聚糖和半乳甘露聚糖检测法更早呈阳性（第3天），而这两种检测法在第5天呈阳性，所有样本在第7天通过每种检测法均呈阳性。

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本文引用的文献

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Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture.通过定量PCR、半乳甘露聚糖酶免疫测定和定量培养评估豚鼠肺组织中烟曲霉负荷量。
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Development of an immunochromatographic lateral-flow device for rapid serodiagnosis of invasive aspergillosis.用于侵袭性曲霉病快速血清学诊断的免疫层析侧向流动装置的研发。
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1,3-Beta-D-glucan antigenemia for early diagnosis of invasive fungal infections in neutropenic patients with acute leukemia.1,3-β-D-葡聚糖抗原血症用于急性白血病中性粒细胞减少患者侵袭性真菌感染的早期诊断。
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Diagnosis of invasive aspergillosis using a galactomannan assay: a meta-analysis.使用半乳甘露聚糖检测法诊断侵袭性曲霉病：一项荟萃分析。
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Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection: a prospective feasibility study.半乳甘露聚糖与基于计算机断层扫描的抢先抗真菌治疗在侵袭性真菌感染高危中性粒细胞减少患者中的应用：一项前瞻性可行性研究。
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Antifungal therapy decreases sensitivity of the Aspergillus galactomannan enzyme immunoassay.抗真菌治疗会降低曲霉半乳甘露聚糖酶免疫测定的敏感性。
Clin Infect Dis. 2005 Jun 15;40(12):1762-9. doi: 10.1086/429921. Epub 2005 May 5.
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Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis.实验性侵袭性肺曲霉病中皮质类固醇治疗和化疗在感染及炎症模式上的差异。
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Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome.β-D-葡聚糖作为侵袭性真菌感染的诊断辅助手段：在急性髓系白血病和骨髓增生异常综合征患者中的验证、临界值确定及性能评估
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Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery.采用早期胸部计算机断层扫描和手术改善中性粒细胞减少患者侵袭性肺曲霉病的管理。
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