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髋关节表面置换术后血液金属离子浓度:关节表面置换与伯明翰髋关节表面置换术的比较研究

Blood metal ion concentrations after hip resurfacing arthroplasty: a comparative study of articular surface replacement and Birmingham Hip Resurfacing arthroplasties.

作者信息

Langton D J, Sprowson A P, Joyce T J, Reed M, Carluke I, Partington P, Nargol A V F

机构信息

Joint Replacement Unit, University Hospital of North Tees, Hardwick, Stockton-on-Tees, UK.

出版信息

J Bone Joint Surg Br. 2009 Oct;91(10):1287-95. doi: 10.1302/0301-620X.91B10.22308.

Abstract

There have been no large comparative studies of the blood levels of metal ions after implantation of commercially available hip resurfacing devices which have taken into account the effects of femoral size and inclination and anteversion of the acetabular component. We present the results in 90 patients with unilateral articular surface replacement (ASR) hip resurfacings (mean time to blood sampling 26 months) and 70 patients with unilateral Birmingham Hip Resurfacing (BHR) implants (mean time 47 months). The whole blood and serum chromium (Cr) and cobalt (Co) concentrations were inversely related to the size of the femoral component in both groups (p < 0.05). Cr and Co were more strongly influenced by the position of the acetabular component in the case of the ASR, with an increase in metal ions observed at inclinations > 45 degrees and anteversion angles of < 10 degrees and > 20 degrees. These levels were only increased in the BHR group when the acetabular component was implanted with an inclination > 55 degrees. A significant relationship was identified between the anteversion of the BHR acetabular component and the levels of Cr and Co (p < 0.05 for Co), with an increase observed at anteversion angles < 10 degrees and > 20 degrees. The median whole blood and serum Cr concentrations of the male ASR patients were significantly lower than those of the BHR men (p < 0.001). This indicates that reduced diametral clearance may equate to a reduction in metal ion concentrations in larger joints with satisfactory orientation of the acetabular component.

摘要

尚未有针对市售髋关节表面置换装置植入后金属离子血药浓度的大型比较研究,这些研究考虑了股骨尺寸以及髋臼部件的倾斜度和前倾角的影响。我们呈现了90例接受单侧关节表面置换(ASR)髋关节表面置换术患者(平均采血时间26个月)和70例接受单侧伯明翰髋关节表面置换(BHR)植入术患者(平均时间47个月)的结果。两组患者全血和血清中的铬(Cr)和钴(Co)浓度均与股骨部件尺寸呈负相关(p < 0.05)。在ASR病例中,Cr和Co受髋臼部件位置的影响更大,在倾斜度> 45度、前倾角< 10度和> 20度时观察到金属离子增加。仅当髋臼部件以> 55度的倾斜度植入时,BHR组中的这些水平才会增加。BHR髋臼部件的前倾角与Cr和Co水平之间存在显著相关性(Co的p < 0.05),在前倾角< 10度和> 20度时观察到水平增加。男性ASR患者的全血和血清Cr浓度中位数显著低于BHR男性患者(p < 0.001)。这表明在髋臼部件方向满意的较大关节中,直径间隙减小可能等同于金属离子浓度降低。

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