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孕妇、脐血和健康成年女性循环树突状细胞亚群的差异。

Differences in circulating dendritic cell subtypes in pregnant women, cord blood and healthy adult women.

机构信息

Department of Laboratory Medicine, Seoul National University Boramae Hospital, Seoul, Korea.

出版信息

J Korean Med Sci. 2009 Oct;24(5):853-9. doi: 10.3346/jkms.2009.24.5.853. Epub 2009 Sep 23.

DOI:10.3346/jkms.2009.24.5.853
PMID:19794983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2752768/
Abstract

Different subtypes of dendritic cells (DC) influence the differentiation of naíve T lymphocytes into T helper type 1 (Th1) and Th2 effector cells. We evaluated the percentages of DC subtypes in peripheral blood from pregnant women (maternal blood) and their cord blood compared to the peripheral blood of healthy non pregnant women (control). Circulating DC were identified by flow cytometry as lineage (CD3, CD14, CD16, CD19, CD20, and CD56)-negative and HLA-DR-positive cells. Subtypes of DC were further characterized as myeloid DC (CD11c(+)/CD123(+/-)), lymphoid DC (CD11c(-)/CD123(+++)) and less differentiated DC (CD11c(-)/CD123(+/-)). The frequency of DC out of all nucleated cells was significantly lower in maternal blood than in control (P<0.001). The ratio of myeloid DC/lymphoid DC was significantly higher in maternal blood than in control (P<0.01). HLA-DR expressions of myeloid DC as mean fluorescence intensity (MFI) were significantly less in maternal blood and in cord blood than in control (P<0.001, respectively). The DC differentiation factors, TNF-alpha and GM-CSF, released from mononuclear cells after lipopolysaccharide stimulation were significantly lower in maternal blood than in control (P<0.01). The distribution of DC subtypes was different in maternal and cord blood from those of non-pregnant women. Their role during pregnancy remains to be determined.

摘要

不同亚型的树突状细胞（DC）影响初始 T 淋巴细胞向 Th1 和 Th2 效应细胞的分化。我们评估了孕妇（产妇血液）及其脐带血中 DC 亚群与健康未怀孕女性（对照组）外周血中的百分比。通过流式细胞术将循环 DC 鉴定为谱系（CD3、CD14、CD16、CD19、CD20 和 CD56）阴性和 HLA-DR 阳性细胞。进一步将 DC 亚型特征化为髓样 DC（CD11c(+)/CD123(+/-)）、淋巴样 DC（CD11c(-)/CD123(+++)）和分化程度较低的 DC（CD11c(-)/CD123(+/-)）。产妇血液中 DC 在外周血中所有有核细胞中的频率明显低于对照组（P<0.001）。产妇血液中髓样 DC/淋巴样 DC 的比例明显高于对照组（P<0.01）。产妇血液和脐带血中髓样 DC 的 HLA-DR 表达（以平均荧光强度（MFI）表示）明显低于对照组（P<0.001，分别）。脂多糖刺激后单核细胞释放的 DC 分化因子 TNF-α和 GM-CSF 在产妇血液中的水平明显低于对照组（P<0.01）。产妇和脐带血中 DC 亚群的分布与未怀孕女性的分布不同。它们在怀孕期间的作用仍有待确定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca22/2752768/36ec5eb7393b/jkms-24-853-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca22/2752768/470d55045ead/jkms-24-853-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca22/2752768/558ea44b4273/jkms-24-853-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca22/2752768/63481781656e/jkms-24-853-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca22/2752768/36ec5eb7393b/jkms-24-853-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca22/2752768/470d55045ead/jkms-24-853-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca22/2752768/558ea44b4273/jkms-24-853-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca22/2752768/63481781656e/jkms-24-853-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca22/2752768/36ec5eb7393b/jkms-24-853-g004.jpg

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