Bayat Mohammad, Azari Afsaneh, Golmohammadi Mohammad Ghasem
Physical Therapy Research Group, Academic Center for Education, Culture, and Research, Iran Medical Science Branch University, Vanak, Tehran, Iran.
Photomed Laser Surg. 2010 Aug;28(4):465-70. doi: 10.1089/pho.2008.2450.
The aim of the present investigation is to evaluate the effects of a 780-nm low-level laser on open skin wound healing.
Optimal parameters of low-level laser therapy (LLLT) for wound healing are discussed.
One full-thickness skin wound was surgically induced in the dorsum skin of 30 rats. The rats were divided into two groups. Rats in the experimental group were daily treated with a gallium aluminum arsenide (GaAlAs) laser (2 J/cm(2), lambda = 780 nm, pulse frequency of 2336 Hz). Rats in the sham-exposed group received LLLT with switched off equipment. After 4, 7, and 15 days, wounds were checked by histological and biomechanical methods. Data were analyzed by the Mann-Whitney U-test.
Fibroblasts, endothelium of blood vessels, blood vessel sections, and maximum stress were significantly increased, whereas macrophages were significantly decreased, compared with those of the sham-exposed group.
Pulsed LLLT with a 780-nm GaAlAs laser significantly accelerates the process of healing of surgically induced, full-thickness skin wounds in rat.
本研究旨在评估780纳米低强度激光对开放性皮肤伤口愈合的影响。
讨论了用于伤口愈合的低强度激光疗法（LLLT）的最佳参数。
在30只大鼠的背部皮肤手术造成一个全层皮肤伤口。将大鼠分为两组。实验组大鼠每天用砷化镓铝（GaAlAs）激光（2 J/cm²，波长=780纳米，脉冲频率2336赫兹）治疗。假照射组大鼠用关闭设备的方式接受低强度激光疗法。在4天、7天和15天后，通过组织学和生物力学方法检查伤口。数据用曼-惠特尼U检验进行分析。
与假照射组相比，成纤维细胞、血管内皮、血管切片和最大应力显著增加，而巨噬细胞显著减少。
用780纳米GaAlAs激光进行脉冲低强度激光疗法可显著加速大鼠手术造成的全层皮肤伤口的愈合过程。
