Lee Won-Jae
Division of Life and Pharmaceutical Science, Department of Life Science, Ewha Woman's University, and National Creative Research Initiative Center for Symbiosystem, Seoul 120-750, South Korea.
Genes Dev. 2009 Oct 1;23(19):2260-5. doi: 10.1101/gad.1858709.
Although it is widely accepted that dynamic cross-talk between gut epithelia and microorganisms must occur to achieve gut homeostasis, the critical mechanisms by which gut-microbe interactions are regulated remain uncertain. In this issue of Genes & Development, Buchon and colleagues (pp. 2333-2344) revealed that the reaction of the gut to microorganisms is not restricted to activating immune systems, but extends to integrated responses essential for gut tissue homeostasis, including self-renewal and the differentiation of stem cells. Further investigation of the connection between immune response and stem cell regulation at the molecular level in the microbe-laden mucosal epithelia will accelerate our understanding of the regulatory mechanisms of gut homeostasis and of the pathogenesis of diseases such as chronic inflammatory diseases and colorectal cancers.
尽管人们普遍认为，肠道上皮细胞与微生物之间必须发生动态相互作用才能实现肠道稳态，但肠道微生物相互作用的调控关键机制仍不明确。在本期《基因与发育》中，布乔恩及其同事（第2333 - 2344页）揭示，肠道对微生物的反应不仅限于激活免疫系统，还扩展到对肠道组织稳态至关重要的综合反应，包括自我更新和干细胞分化。在充满微生物的黏膜上皮细胞中，从分子水平进一步研究免疫反应与干细胞调控之间的联系，将加速我们对肠道稳态调控机制以及慢性炎症性疾病和结直肠癌等疾病发病机制的理解。
