Effects of early malnutrition on mental system, metabolic syndrome, immunity and the gastrointestinal tract.

The notion of how malnutrition early in life affects ontogenesis has evolved considerably since the mid-1960s. Since then, there have been many studies on the effects of early malnutrition. Nutritional and metabolic exposure during critical periods in early human and animal development may have long-term programming effects in adulthood. This is supported by evidence from epidemiological studies, numerous animal models and clinical intervention trials. In this paper, we review the effects of early malnutrition on cognitive function, metabolic syndrome, immunity and the gastrointestinal tract, as well as possible underlying mechanisms, and consider diarrhoeal disease and poor cognitive function as examples for understanding the interrelation of the harmful effects caused by early malnutrition. Previous studies on early malnutrition have mainly concentrated on humans and rats. Therefore, the main aim of the present review was to give animal scientists a clear understanding of the harmful effects of early malnutrition on animal growth and animal production, and to help identify appropriate feeding techniques to prevent early malnutrition.