Kleine Henning, Lüscher Bernhard
Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany.
Cell. 2009 Oct 2;139(1):17-9. doi: 10.1016/j.cell.2009.09.018.
ADP-ribosylation is a posttranslational modification that is emerging as a broadly used mechanism to regulate the functions of proteins and their interactions. Recent findings by three groups (Ahel et al., 2009; Gottschalk et al., 2009; Timinszky et al., 2009) establish that proteins with macrodomains bind poly-ADP-ribose to mediate the cellular response to DNA damage.
ADP核糖基化是一种翻译后修饰,正逐渐成为一种广泛用于调节蛋白质功能及其相互作用的机制。最近三个研究小组(阿赫尔等人,2009年;戈特沙尔克等人,2009年;蒂明斯基等人,2009年)的研究结果表明,含有大结构域的蛋白质会结合多聚ADP核糖,以介导细胞对DNA损伤的反应。