Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-17177 Stockholm, Sweden.
Mol Aspects Med. 2013 Dec;34(6):1088-108. doi: 10.1016/j.mam.2013.02.002. Epub 2013 Feb 28.
ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation.
ADP-核糖基化蛋白调节各种过程中的蛋白质活性，包括转录调控、染色质组织、细胞器组装、蛋白质降解和 DNA 修复。调节 ADP-核糖基化代谢过程中涉及的蛋白质可能在各种疾病状态中具有治疗益处。蛋白质晶体结构可以帮助理解生物功能，促进对单个残基的详细分析，并为小分子效应物的开发提供基础。在这里，我们回顾了对 ADP-核糖基化的写入器、读取器和擦除器的结构生物学的理解的最新进展。
