Haseeb Abdul, Iliyas Mohammad, Chakrabarti Subhabrata, Farooqui Arif A, Naik Sudhir R, Ghosh Sudip, Suragani Madhuri, Ehtesham Nasreen Z
Molecular Biology Unit, National Institute of Nutrition, Jamai Osmania, Hyderabad 500 604, India.
J Biosci. 2009 Sep;34(3):405-14. doi: 10.1007/s12038-009-0047-x.
Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations. However, association of these polymorphisms with the metabolic syndrome and its individual components has not been well investigated in the Indian population. The Indian population harbours the maximum number of diabetics in the world who are thus more susceptible to metabolic disorders. We screened a South Indian population (N=699) for a possible association of these polymorphisms with the metabolic syndrome (MS) and type 2 diabetes. We also investigated the correlation of these two single-nucleotide polymorphisms (SNPs) with plasma resistin levels. The C1431T SNP was associated with higher levels of plasma resistin (P=0.017). Furthermore, C1431T was associated with resistin in different tertiles. Prevalence of the 'Pro-C' haplotype decreased with increasing tertiles of resistin (84.1% to 75.4%, P=0.037). Plasma resistin levels were not found to be associated with MS and type 2 diabetes. These results point to a likely association of plasma resistin levels with PPAR? polymorphisms in the Indian population.
关于过氧化物酶体增殖物激活受体γ（PPARγ）的Pro12Ala和C1431T多态性与糖尿病及肥胖症之间关联的研究已揭示出广泛的人群依赖性差异。然而，在印度人群中，这些多态性与代谢综合征及其各个组分之间的关联尚未得到充分研究。印度是世界上糖尿病患者人数最多的国家，因此更容易患代谢紊乱疾病。我们对南印度人群（N = 699）进行了筛查，以研究这些多态性与代谢综合征（MS）及2型糖尿病之间可能存在的关联。我们还研究了这两种单核苷酸多态性（SNP）与血浆抵抗素水平之间的相关性。C1431T SNP与较高的血浆抵抗素水平相关（P = 0.017）。此外，C1431T在不同三分位数水平与抵抗素相关。“Pro - C”单倍型的患病率随着抵抗素三分位数水平的升高而降低（84.1%至75.4%，P = 0.037）。未发现血浆抵抗素水平与MS及2型糖尿病相关。这些结果表明，在印度人群中，血浆抵抗素水平可能与PPARγ多态性存在关联。
