Kim Soo Jeong, Lim Kyung Sook, Song Mi Sook, Kang Yeonji, Lee Soon Young
Institute of Human Genomic Study, Korea University Medical Center Ansan Hospital.
J Prev Med Public Health. 2009 Sep;42(5):337-42. doi: 10.3961/jpmph.2009.42.5.337.
Many previous studies have shown that elevated homocysteine in the serum is a well known risk factor for cardiovascular disease and this is associated with other risk factors for cardiovascular disease, but any Korean data on this is limited.
This study aimed to calculate the prevalence of hyperhomocysteinemia and to analyze the relation between elevated homocysteine and the lifestyle factors of Korean adults.
We conducted a cross-sectional survey that included 650 men and 743 women (age range, 20 to 79 years) who were residents of Gwangju City in Gyeonggi-do. These subjects participated in the health interview and examination survey from November to December 2005. The total homocysteine, total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride in the serum were measured. All the participants had their body composition measured such as height and weight, and we obtained health-related behavioral information through the self-entry questionnaire.
Very right-handed skewed distributions of homocysteine were shown in men and women. The prevalence of hyperhomocysteinemia was 22.6% in men and 13.7% in women in Gwangju city. On the multiple logistic regression analysis, hyperhomocysteinemia was associated with age (OR=1.02, 95% CI=1.01-1.04), male gender (OR=1.60, 95% CI=1.02-2.52), severe general physical activity (OR=0.32, 95% CI=0.15-0.69) and nutrient consumption (OR=0.49, 95% CI=0.31-0.76).
There is a great prevalence of hyperhomocysteinemia in adults of Gwangju City, Korea and it was associated with both genetic factors and lifestyle risk factors. This study can suggest that comprehensive lifestyle modification is needed in order to diminish the prevalence of hyperhomocysteinemia and to prevent CVD.
许多先前的研究表明，血清中同型半胱氨酸水平升高是心血管疾病的一个众所周知的危险因素，且这与心血管疾病的其他危险因素相关，但韩国在这方面的数据有限。
本研究旨在计算高同型半胱氨酸血症的患病率，并分析韩国成年人同型半胱氨酸水平升高与生活方式因素之间的关系。
我们进行了一项横断面调查，纳入了650名男性和743名女性（年龄范围为20至79岁），他们均为京畿道广州市的居民。这些受试者于2005年11月至12月参加了健康访谈和检查调查。测量了血清中的总同型半胱氨酸、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯。所有参与者都测量了身体成分，如身高和体重，并且我们通过自填问卷获得了与健康相关的行为信息。
男性和女性的同型半胱氨酸分布均呈极右偏态。广州市男性高同型半胱氨酸血症的患病率为22.6%，女性为13.7%。在多因素逻辑回归分析中，高同型半胱氨酸血症与年龄（OR = 1.02，95%CI = 1.01 - 1.04）、男性性别（OR = 1.60，95%CI = 1.02 - 2.52）、剧烈的一般体力活动（OR = 0.32，95%CI = 0.15 - 0.69）和营养摄入（OR = 0.49，95%CI = 0.31 - 0.76）有关。
韩国广州市成年人中高同型半胱氨酸血症的患病率很高，并且它与遗传因素和生活方式危险因素均有关。本研究表明，需要进行全面的生活方式改变，以降低高同型半胱氨酸血症的患病率并预防心血管疾病。
