Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd, Seoul, Korea.
J Korean Med Sci. 2012 May;27(5):500-5. doi: 10.3346/jkms.2012.27.5.500. Epub 2012 Apr 25.
The aim of this study was to examine whether serum homocysteine (Hcy) levels correlated with cardiovascular disease (CVD) depending on the presence or absence of metabolic syndrome (MetS) in Korean men. We conducted a case-control study, including 138 CVD and 290 non-CVD age-matched control subjects. The subjects were divided into four subgroups: 34 CVD/MetS, 104 CVD, 77 MetS, and 213 normal subgroups. The mean Hcy was significantly higher, whereas HDL and intake of vitamin B(1) and B(2) were lower in the CVD group (P < 0.05) than non-CVD group. When compared to the control group, subjects with CVD/MetS, CVD and MetS exhibited high Hcy levels, with the highest observed in the CVD/MetS subgroup (P < 0.001). Multivariate stepwise linear regression between CVD and markers of CVD showed Hcy significantly correlated with CVD (P < 0.05). To predict CVD based on Hcy, Hcy threshold of 11.72 µM in non-MetS subjects had an area under the curve (AUC) of 0.664 (95% CI 0.598-0.731). In MetS subjects, the AUC was 0.618 and Hcy threshold was 13.32 µM (95% CI 0.509-0.726). The results of our study show that the presence of MetS needs to be considered when using Hcy levels for predicting CVD.
本研究旨在探讨在韩国男性中，血清同型半胱氨酸（Hcy）水平是否与心血管疾病（CVD）相关，以及这种相关性是否取决于代谢综合征（MetS）的存在。我们进行了一项病例对照研究，纳入了 138 例 CVD 患者和 290 例年龄匹配的非 CVD 对照组。将受试者分为四组：34 例 CVD/MetS、104 例 CVD、77 例 MetS 和 213 例正常组。CVD 组的 Hcy 均值显著升高，而 HDL 和维生素 B(1)、B(2)的摄入量则较低（P<0.05）。与对照组相比，CVD/MetS、CVD 和 MetS 患者的 Hcy 水平较高，其中以 CVD/MetS 组最高（P<0.001）。CVD 与 CVD 标志物之间的多元逐步线性回归显示，Hcy 与 CVD 显著相关（P<0.05）。根据 Hcy 预测 CVD 时，非 MetS 患者的 Hcy 阈值为 11.72µM 时，曲线下面积（AUC）为 0.664（95%CI 0.598-0.731）。在 MetS 患者中，AUC 为 0.618，Hcy 阈值为 13.32µM（95%CI 0.509-0.726）。我们的研究结果表明，在使用 Hcy 水平预测 CVD 时，需要考虑 MetS 的存在。
