肠道黏蛋白基因MUC3在染色体7q22上的区域定位。
Regional localization of the intestinal mucin gene MUC3 to chromosome 7q22.
作者信息
Fox M F, Lahbib F, Pratt W, Attwood J, Gum J, Kim Y, Swallow D M
机构信息
MRC Human Biochemical Genetics Unit, Galton Laboratory, University College London, UK.
出版信息
Ann Hum Genet. 1992 Oct;56(4):281-7. doi: 10.1111/j.1469-1809.1992.tb01154.x.
The gene MUC3 which codes for a mucin expressed in intestine (Gum et al. 1990) has previously been mapped, using somatic cell hybrids, to chromosome 7. We describe here the regional localization of MUC3 to chromosome 7q22 by in situ hybridization. Preliminary linkage analysis using CEPH (Centre d'Etude du Polymorphisme Humain) families supports this assignment and places MUC3 in the same linkage group as COL1A2 and CFTR.
编码在肠道中表达的一种粘蛋白的MUC3基因（Gum等人，1990年）先前已利用体细胞杂种定位到7号染色体上。我们在此通过原位杂交描述了MUC3在7号染色体q22区域的定位。使用CEPH（人类多态性研究中心）家系进行的初步连锁分析支持这一定位，并将MUC3置于与COL1A2和CFTR相同的连锁群中。
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