吸烟对不育夫妇控制性卵巢刺激和宫腔内人工授精结局的影响。
Influence of smoking on outcome of COH and IUI in subfertile couples.
作者信息
Farhi Jacob, Orvieto Raoul
机构信息
Fertility Clinics, Ashdod and Holon Women's Health Centers, Clalit Medical Services, Tel Aviv, Israel.
出版信息
J Assist Reprod Genet. 2009 Jul;26(7):421-4. doi: 10.1007/s10815-009-9330-x. Epub 2009 Sep 15.
AIM
To evaluate the influence of smoking on the outcome of COH and IUI in subfertile couples.
PATIENTS AND METHODS
We reviewed the medical files of all consecutive women, age </=35 years, attending our infertility clinics over an eigth-year period. Data on patient age, smoking habits, and variable related to infertility-treatment were collected from the files.
RESULTS
A total of 2,318 cases were evaluated: 1,803 in nonsmoking patients (n = 679) and 515 in smokers (n = 206). The smokers used significantly more gonadotropin ampoules and gained a thinner endometrium on the day of hCG administration than the nonsmokers (p < 0.016 for both). There were no between-groups differences in patient age, duration of gonadotropin stimulation, number of follicle >14 mm in diameter, or E2 levels on the day of hCG administration.
CONCLUSION
Smokers undergoing COH with IUI required a significantly higher gonadotropin dosage than nonsmokers in order to achieved a comparable pregnancy rate.
目的
评估吸烟对不育夫妇控制性卵巢刺激（COH）及宫腔内人工授精（IUI）结局的影响。
患者与方法
我们回顾了连续8年内在我院不育门诊就诊的所有年龄≤35岁女性的病历。从病历中收集患者年龄、吸烟习惯以及与不育治疗相关的变量数据。
结果
共评估2318例病例：非吸烟患者1803例（n = 679），吸烟患者515例（n = 206）。与非吸烟者相比，吸烟者使用的促性腺激素安瓿显著更多，且在注射人绒毛膜促性腺激素（hCG）当天子宫内膜更薄（两者均p < 0.016）。两组在患者年龄、促性腺激素刺激持续时间、直径>14 mm卵泡数量或注射hCG当天的雌二醇（E2）水平方面无差异。
结论
接受COH联合IUI的吸烟者为达到可比的妊娠率，所需的促性腺激素剂量显著高于非吸烟者。
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