经颅磁刺激治疗失语症的研究。
Research with transcranial magnetic stimulation in the treatment of aphasia.
作者信息
Martin Paula I, Naeser Margaret A, Ho Michael, Treglia Ethan, Kaplan Elina, Baker Errol H, Pascual-Leone Alvaro
机构信息
Aphasia Research Center 12-A, VA Boston Healthcare System, Boston, MA 02130, USA.
出版信息
Curr Neurol Neurosci Rep. 2009 Nov;9(6):451-8. doi: 10.1007/s11910-009-0067-9.
Abstract
Repetitive transcranial magnetic stimulation (rTMS) has been used to improve language behavior, including naming, in stroke patients with chronic, nonfluent aphasia. Part 1 of this article reviews functional imaging studies related to language recovery in aphasia. Part 2 reviews the rationale for using rTMS to treat nonfluent aphasia (based on functional imaging) and presents our current rTMS protocol. We present language results from our rTMS studies as well as imaging results from overt naming functional MRI scans obtained before and after a series of rTMS treatments. Part 3 presents results from a pilot study in which rTMS treatments were followed immediately by constraint-induced language therapy. Part 4 reviews our diffusion tensor imaging study examining the possible connectivity of the arcuate fasciculus to different parts of Broca's area (pars triangularis, pars opercularis) and to the ventral premotor cortex. The potential role of mirror neurons in the right pars opercularis and ventral premotor cortex in aphasia recovery is discussed.
摘要
重复经颅磁刺激（rTMS）已被用于改善慢性非流利性失语症中风患者的语言行为，包括命名。本文的第一部分回顾了与失语症语言恢复相关的功能成像研究。第二部分回顾了使用rTMS治疗非流利性失语症的理论基础（基于功能成像），并介绍了我们目前的rTMS方案。我们展示了rTMS研究的语言结果以及一系列rTMS治疗前后获得的公开命名功能磁共振成像扫描的成像结果。第三部分展示了一项初步研究的结果，在该研究中，rTMS治疗后立即进行了强制性语言治疗。第四部分回顾了我们的扩散张量成像研究，该研究检查了弓状束与布洛卡区不同部分（三角部、岛盖部）以及腹侧运动前皮层之间可能的连接性。讨论了右岛盖部和腹侧运动前皮层中的镜像神经元在失语症恢复中的潜在作用。
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