Vittoria A, La Mura E, Cocca T, Cecio A
Department of Biological Structures, Functions and Technology, University of Naples Federico II, Italy.
J Anat. 1990 Aug;171:169-78.
The urethral and prostatic epithelial of the sheep contain a large number of amine- and/or peptide-producing neuroendocrine cells (NE), also called paraneurons. Four different cell types have been immunohistochemically recognised among them. The first contains the amine serotonin, the second the protein chromogranin A, the third the amine and the protein together and the fourth the hormone somatostatin. Serotonin-producing cells are elongated in shape and often show cytoplasmic dendrite-like processes directed towards the basal membrane and/or the lumen. Chromogranin A-containing cells are polymorphic and constitute the more numerous NE subpopulation. Cells containing both the bioactive substances seem to be less numerous than the chromogranin A cells and slightly more frequent than the serotonin cells. All these cell types are diffused along the whole urethro-prostatic complex and show their highest density in the collicular zone. Somatostatin-containing cells often show a unique cytoplasmic extension directed towards the basal membrane and are rare. It is supposed that the presence of serotonin in the urogenital tract is functionally correlated with the emission of urine and/or semen, while somatostatin is associated with the inhibition of local exocrine and/or endocrine secretions.
绵羊的尿道和前列腺上皮含有大量产生胺和/或肽的神经内分泌细胞（NE），也称为副神经元。其中已通过免疫组织化学识别出四种不同的细胞类型。第一种含有胺5-羟色胺，第二种含有蛋白质嗜铬粒蛋白A，第三种同时含有胺和蛋白质，第四种含有激素生长抑素。产生5-羟色胺的细胞呈细长形，常显示出指向基底膜和/或管腔的细胞质树突状突起。含嗜铬粒蛋白A的细胞多形性，构成数量较多的NE亚群。同时含有这两种生物活性物质的细胞似乎比嗜铬粒蛋白A细胞数量少，比5-羟色胺细胞稍多。所有这些细胞类型沿整个尿道-前列腺复合体分布，在丘状区密度最高。含生长抑素的细胞常显示出指向基底膜的独特细胞质延伸，且数量稀少。推测泌尿生殖道中5-羟色胺的存在在功能上与尿液和/或精液的排出相关，而生长抑素与局部外分泌和/或内分泌分泌的抑制有关。
