Li Xuehua, Xu Yihua, Nie Shaofa, Xiang Hao, Wang Chongjian
Department of Epidemiology and Statistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
J Huazhong Univ Sci Technolog Med Sci. 2009 Oct;29(5):580-4. doi: 10.1007/s11596-009-0510-9. Epub 2009 Oct 11.
The effects of highly active antiretroviral therapy (HAART) to patients with AIDS in Hubei province of China were investigated in order to provide scientific evidence to reinforce the management of HAART. Self-made questionnaires and descriptive method of epidemiology were used to collect and describe the changes of clinical symptoms, HIV RNA concentration, and immune function of patients with AIDS. After HAART, the effective rate of fever, cough, diarrhea, lymphadenectasis, weight loss, tetter, debility and fungous infection was 92.4%, 90.85%, 92.91%, 90.73%, 93.69%, 89.04%, 92.34%, and 83.1%, respectively. Of 117 patients with detected HIV RNA concentration, 41.03% had declined over 0.5 log, and 52.99% less than 0.5 log. CD4(+)T cell count was obviously increased: the average number after HAART for 3 or 6 months was 237/microL (26-755/microL) and 239/microL (17-833/microL), respectively. HAART can improve AIDS patients' clinical symptoms, reduce HIV RNA concentration, and maintain immune function. It is very important for the effectiveness of HAART to raise clinical adherence of patients with AIDS and have a persistent surveillance.
为了为加强高效抗逆转录病毒治疗（HAART）管理提供科学依据，对中国湖北省艾滋病患者接受HAART的效果进行了调查。采用自制问卷和流行病学描述方法，收集并描述艾滋病患者的临床症状、HIV RNA浓度及免疫功能变化。HAART治疗后，发热、咳嗽、腹泻、淋巴结肿大、体重减轻、皮疹、乏力及真菌感染的有效率分别为92.4%、90.85%、92.91%、90.73%、93.69%、89.04%、92.34%和83.1%。在117例检测HIV RNA浓度的患者中，41.03%下降超过0.5 log，52.99%下降小于0.5 log。CD4(+)T细胞计数明显增加：HAART治疗3个月和6个月后的平均数量分别为237/μL（26 - 755/μL）和239/μL（17 - 833/μL）。HAART可改善艾滋病患者的临床症状，降低HIV RNA浓度，并维持免疫功能。提高艾滋病患者的临床依从性并进行持续监测对HAART的有效性非常重要。
