Kalix P
Département de Pharmacologie, Centre Médical Universitaire, Geneva, Switzerland.
Pharmacol Ther. 1990;48(3):397-416. doi: 10.1016/0163-7258(90)90057-9.
The chewing of the stimulant leaf khat is a habit that is widespread in certain countries of East Africa and the Arabian peninsula. During the last decade, important progress has been made in understanding the pharmacological basis for the effects of khat. It is now known that the CNS action of this drug is due to the presence of the alkaloid cathinone, and the results of various in vitro and in vivo experiments indicate that this substance must be considered a natural amphetamine. It is the purpose of the present review to describe briefly the khat habit and to summarize the pharmacology of khat and of its active constituents.
咀嚼兴奋剂恰特草叶是一种在东非某些国家和阿拉伯半岛广泛存在的习惯。在过去十年中，在理解恰特草作用的药理学基础方面取得了重要进展。现在已知这种药物对中枢神经系统的作用归因于生物碱卡西酮的存在，各种体外和体内实验的结果表明，这种物质必须被视为一种天然安非他命。本综述的目的是简要描述恰特草习惯，并总结恰特草及其活性成分的药理学。
