Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
IEEE Trans Biomed Eng. 2010 Apr;57(4):953-9. doi: 10.1109/TBME.2009.2033464. Epub 2009 Oct 9.
Dynamic optical coherence elastography is used to determine in vivo skin biomechanical properties based on mechanical surface wave propagation. Quantitative Young's moduli are measured on human skin from different sites, orientations, and frequencies. Skin thicknesses, including measurements from different layers, are also measured simultaneously. Experimental results show significant differences among measurements from different skin sites, between directions parallel and orthogonal to Langer's lines, and under different skin hydration states. Results also suggest surface waves with different driving frequencies represent skin biomechanical properties from different layers in depth. With features such as micrometer-scale resolution, noninvasive imaging, and real-time processing from the optical coherence tomography technology, this optical measurement technique has great potential for measuring skin biomechanical properties in dermatology.
动态光学相干弹性成像用于基于机械表面波传播来确定体内皮肤生物力学特性。在人体皮肤的不同部位、方位和频率下测量定量杨氏模量。同时还测量了皮肤厚度，包括来自不同层的测量值。实验结果表明，不同皮肤部位的测量值、与朗格线平行和垂直的方向之间以及不同皮肤水合状态下的测量值存在显著差异。结果还表明，具有不同驱动频率的表面波代表了深度不同层的皮肤生物力学特性。由于光学相干断层扫描技术具有亚毫米级分辨率、非侵入性成像和实时处理等特点，这种光学测量技术在皮肤科测量皮肤生物力学特性方面具有很大的潜力。
