Amity Institute of Virology and Immunology, Amity University, Sector 125, Noida 201313, Uttar Pradesh, India.
Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad 500046, Telengana, India.
Int J Mol Sci. 2019 May 16;20(10):2432. doi: 10.3390/ijms20102432.
Perturbation in the microbial population/colony index has harmful consequences on human health. Both biological and social factors influence the composition of the gut microbiota and also promote gastric diseases. Changes in the gut microbiota manifest in disease progression owing to epigenetic modification in the host, which in turn influences differentiation and function of immune cells adversely. Uncontrolled use of antibiotics, chemotherapeutic drugs, and any change in the diet pattern usually contribute to the changes in the colony index of sensitive strains known to release microbial content in the tissue micromilieu. Ligands released from dying microbes induce Toll-like receptor (TLR) mimicry, skew hypoxia, and cause sterile inflammation, which further contributes to the severity of inflammatory, autoimmune, and tumorous diseases. The major aim and scope of this review is both to discuss various modalities/interventions across the globe and to utilize microbiota-based therapeutic approaches for mitigating the disease burden.
微生物种群/菌落指数的紊乱会对人类健康造成有害影响。生物和社会因素都会影响肠道微生物群的组成，并促进胃部疾病的发生。由于宿主的表观遗传修饰，肠道微生物群的变化会在疾病进展中表现出来，进而对免疫细胞的分化和功能产生不利影响。抗生素、化疗药物的滥用以及饮食模式的任何改变通常都会导致已知释放组织微环境中微生物含量的敏感菌株的菌落指数发生变化。死亡微生物释放的配体诱导 Toll 样受体 (TLR) 模拟，使缺氧倾斜，并导致无菌性炎症，这进一步加剧了炎症、自身免疫和肿瘤性疾病的严重程度。本综述的主要目的和范围是讨论全球各种模式/干预措施，并利用基于微生物组的治疗方法来减轻疾病负担。
