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在泉古菌门和奇古菌门中鉴定出真核生物RNA聚合酶III亚基RPC34的直系同源物，这表明古菌中RNA聚合酶在编码和非编码RNA方面存在特化现象。

Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea.

作者信息

Blombach Fabian, Makarova Kira S, Marrero Jeannette, Siebers Bettina, Koonin Eugene V, van der Oost John

机构信息

Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands.

出版信息

Biol Direct. 2009 Oct 14;4:39. doi: 10.1186/1745-6150-4-39.

DOI:10.1186/1745-6150-4-39
PMID:19828044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2770514/
Abstract

One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the transcription of specific classes of coding or non-coding RNAs. Archaea encode only one RNA polymerase that resembles the eukaryotic RNA polymerase II with respect to the subunit composition. Here we identify archaeal orthologs of the eukaryotic RNA polymerase III subunit RPC34. Genome context analysis supports a function of this archaeal protein in the transcription of non-coding RNAs. These findings suggest that functional separation of RNA polymerases for protein-coding genes and non-coding RNAs might predate the origin of the Eukaryotes.

摘要

真核生物信息处理的一个标志是存在3种不同的多亚基RNA聚合酶复合物，它们专门负责转录特定类别的编码或非编码RNA。古细菌仅编码一种RNA聚合酶，就亚基组成而言，它类似于真核生物的RNA聚合酶II。在这里，我们鉴定出真核生物RNA聚合酶III亚基RPC34的古细菌直系同源物。基因组背景分析支持这种古细菌蛋白在非编码RNA转录中的功能。这些发现表明，负责蛋白质编码基因和非编码RNA转录的RNA聚合酶的功能分离可能早于真核生物的起源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcff/2770514/002871915ec3/1745-6150-4-39-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcff/2770514/605117628177/1745-6150-4-39-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcff/2770514/4358211c341f/1745-6150-4-39-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcff/2770514/002871915ec3/1745-6150-4-39-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcff/2770514/605117628177/1745-6150-4-39-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcff/2770514/4358211c341f/1745-6150-4-39-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcff/2770514/002871915ec3/1745-6150-4-39-3.jpg

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