Department of Psychiatry, Kasturba Medical College, Attavara, Mangalore, Karnataka, India.
Indian J Psychiatry. 2011 Apr;53(2):163-5. doi: 10.4103/0019-5545.82552.
To report oral topiramate-induced glaucoma and to asses its severity and preventability. A 40-year-old manpresented with watering, redness, pain, and diminution of vision of both eyes, one week after initiation of oral topiramate 100 mg/day for alcohol de-addiction. On examination, both eyes showed conjunctival chemosis, corneal edema, shallow anterior chamber, and intraocular pressure 48 and 46 mm Hg. The symptoms and clinical findings resolved completely upon discontinuation of topiramate and administration of antiglaucoma drugs. Topiramate-induced angle-closure glaucoma and other ocular side effects are reversible if the diagnosis is made early and the drug is discontinued in time. Hence, clinician awareness is an important aspect of preventability of this adverse event.
报告一例口服托吡酯引起的青光眼，并评估其严重程度和可预防性。一名 40 岁男性，因酒精戒断而开始口服托吡酯 100mg/天，一周后出现双眼流泪、眼红、疼痛和视力下降。检查发现双眼结膜水肿、角膜水肿、浅前房和眼压 48 和 46mmHg。停用托吡酯并给予抗青光眼药物后，症状和临床发现完全缓解。如果早期诊断并及时停药，托吡酯引起的闭角型青光眼和其他眼部副作用是可逆的。因此，临床医生的意识是预防这种不良事件的一个重要方面。
