Alzendi Nouf A, Badawi Abdulrahman H, Alhazzaa Bader, Alshahrani Ali, Owaidhah Ohoud
King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Saudi J Ophthalmol. 2021 Feb 27;34(3):202-204. doi: 10.4103/SJOPT.SJOPT_9_20. eCollection 2020 Jul-Sep.
The aim of this study is to report the side effects of oral topiramate in two young patients presented with bilateral ocular blurring and discomfort, causing unique development of secondary acute angle closure (AAC) after discontinuation of oral topiramate. Both patients, with a history of seizure and migraine, respectively, were taking oral topiramate to control their mentioned diseases. Both had secondary AAC and high intraocular pressure, after discontinuing topiramate. They were treated with topical medications and underwent initial and subsequent multimodal imaging to track up their response to the management. Ocular side effect, during topiramate use and possibly even after discontinuation, will improve early detection of secondary AAC. Topical management along with multimodal imaging of such cases can give optimal results.
本研究的目的是报告口服托吡酯在两名年轻患者中的副作用，这两名患者均出现双侧视力模糊和不适，并在停用口服托吡酯后出现了独特的继发性急性闭角型青光眼（AAC）。两名患者分别有癫痫和偏头痛病史，正在服用口服托吡酯来控制上述疾病。停用托吡酯后，两人均出现继发性AAC和高眼压。他们接受了局部用药治疗，并进行了初始及后续的多模态成像检查，以追踪其对治疗的反应。托吡酯使用期间甚至停药后出现的眼部副作用，将有助于早期发现继发性AAC。对此类病例进行局部治疗并结合多模态成像检查可取得最佳效果。
