Karadağ Hasan, Acar Mutlu, Özdel Kadir
Department of Psychiatry, Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
Department of Ophthalmology, Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
Balkan Med J. 2015 Apr;32(2):230-2. doi: 10.5152/balkanmedj.2015.15292. Epub 2015 Apr 1.
Aripiprazole is an atypical antipsychotic drug. Acute transient myopia is a rare response to systemic medication. Unspecified ocular side effects of aripiprazole have rarely been reported. To the best of our knowledge, only 3 cases of aripiprazole induced myopia and diplopia have been reported in the literature. The aim of this article is to present a case of aripiprazole-induced acute transient myopia.
A 30 year-old woman underwent treatment for 5 days with aripiprazole and presented with bilateral painless blurred vision. The patient's uncorrected visual acuity was 2/10 in both eyes and her best corrected visual acuity was 10/10 in both eyes with a refractive error of -3.00 diopters using a standard Snellen chart. Adding 2 mgs of biperiden a day to her treatment regimen decreased her blurred vision symptoms. After discontinuation of aripiprazole treatment and cross-switching to Paliperidon palmitate (75 mg/month) her blurred vision completely resolved. The same side effect did not re-occur when checked on her 6-month follow up.
Ophthalmologists as well as psychiatrists must be aware of this myopic shift and should also ask these patients about medicine usage, especially aripiprazole. Ophthalmologists should consult the prescribing psychiatrist and stop the drug immediately to reverse this temporary condition.
阿立哌唑是一种非典型抗精神病药物。急性短暂性近视是全身用药罕见的不良反应。阿立哌唑未明确的眼部副作用鲜有报道。据我们所知，文献中仅报道了3例阿立哌唑引起的近视和复视。本文旨在介绍1例阿立哌唑引起的急性短暂性近视病例。
一名30岁女性接受阿立哌唑治疗5天后出现双侧无痛性视力模糊。使用标准斯内伦视力表检查，患者双眼裸眼视力均为2/10，最佳矫正视力均为10/10，屈光不正为-3.00屈光度。在其治疗方案中每天加用2毫克苯海索可减轻其视力模糊症状。停用阿立哌唑治疗并换用棕榈酸帕利哌酮（每月75毫克）后，其视力模糊完全缓解。在6个月随访检查时未再次出现相同副作用。
眼科医生和精神科医生均必须意识到这种近视变化，还应询问这些患者的用药情况，尤其是阿立哌唑。眼科医生应咨询开具处方的精神科医生并立即停药以扭转这种暂时状况。
