Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Planta Med. 2010 Mar;76(5):461-4. doi: 10.1055/s-0029-1186194. Epub 2009 Oct 14.
Column chromatographic isolation of the MeOH extract of the seeds of Amomum xanthioides afforded a new diterpene glycoside, amoxanthoside A (1), two new monoterpene glycosides, (1 S,4 S,5 S)-5- EXO-hydroxycamphor 5-O-beta-D-glucopyranoside (2) and (1 R,4 R,5 S)-5-ENDO-hydroxycamphor 5-O-beta-D-glucopyranoside (3), together with four known compounds, hedychiol A (4), pygmol (5), (1 S,4 R,6 R)-(+)-6- ENDO-hydroxycamphor (6), and dihydroyashabushiketol (7). The structures of the new compounds were determined through spectral analysis, including extensive 2D NMR data. The isolated compounds were tested for their cytotoxicity against four human cancer cell lines IN VITRO using a sulforhodamine B bioassay.
采用柱层析分离方法，从阳春砂种子的甲醇提取物中分离得到一个新的二萜糖苷，即莪术呋喃苷 A（1），两个新的单萜糖苷，（1S,4S,5S）-5- EXO-羟基莰烷-5-O-β-D-吡喃葡萄糖苷（2）和（1R,4R,5S）-5-ENDO-羟基莰烷-5-O-β-D-吡喃葡萄糖苷（3），以及四个已知化合物，荜澄茄醇 A（4），胡椒醇（5），（1S,4R,6R）-（+）-6- ENDO-羟基莰烷（6）和二氢鸦胆子醇酮（7）。通过光谱分析，包括广泛的 2D NMR 数据，确定了新化合物的结构。采用磺基罗丹明 B 生物测定法，在体外测试了分离得到的化合物对四种人癌细胞系的细胞毒性。
