State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
Phytochemistry. 2012 Nov;83:63-9. doi: 10.1016/j.phytochem.2012.07.013. Epub 2012 Sep 6.
Labdane diterpene glycosides cathargyroside A and cathargyroside B, monoterpene glycosides vervenone-10-O-β-D-glucopyranoside and vervenone-10-O-β-D-apiofuranosyl-(1″→6')-β-D-glucopyranoside, as well as lignan glycosides cedrusinin-4-O-α-L-rhamnopyranoside and (+)-cyclo-olivil-9'-O-β-D-xylopyranoside, along with 39 known compounds, were obtained from the methanol extract of the twigs and leaves of Cathaya argyrophylla. These compounds were identified mainly by analyzing their NMR and MS data. Almost all of these compounds were hitherto unknown in this genus. The isolated compounds were screened against Candida albicans and Staphylococcus aureus for antimicrobial assay, and against K562, HT-29, BEL-7402, SGC-7901, B16, BGC-823, U251 and A549 cancer cell lines for cytotoxic activities. One compound showed antimicrobial activity against C. albicans, and four of them displayed cytotoxicity. Similarity analysis on the chemical constituents of the genera Cathaya, Picea and Pinus supported their close phylogenetic relationships.
从银杉的嫩枝和叶片甲醇提取物中分离得到了 labdane 二萜糖苷 cathargyroside A 和 cathargyroside B、单萜糖苷 vervenone-10-O-β-D-吡喃葡萄糖苷和 vervenone-10-O-β-D-吡喃阿戊糖苷、以及木脂素糖苷 cedrusinin-4-O-α-L-鼠李吡喃糖苷和 (+)-cyclo-olivil-9'-O-β-D-吡喃木糖苷，此外还分离得到了 39 种已知化合物。这些化合物主要通过分析其 NMR 和 MS 数据进行鉴定。这些化合物在该属中几乎都是前所未知的。对分离得到的化合物进行了抗白色念珠菌和金黄色葡萄球菌的抗菌活性筛选，以及对 K562、HT-29、BEL-7402、SGC-7901、B16、BGC-823、U251 和 A549 癌细胞系的细胞毒性筛选。有一个化合物对白色念珠菌具有抗菌活性，有四个化合物具有细胞毒性。对银杉属、松属和云杉属的化学成分进行相似性分析，支持它们具有密切的系统发育关系。
