Fontaine J, Favre H, Valette L, Précausta P, Roulet C, Brun A, Terré J
Dev Biol Stand. 1976;35:395-407.
Combined vaccines are used for many human and animal diseases. However, we have very few examples of combinations containing anti-foot-and-mouth valence which would allow easy immunization against differnet diseases without additional handling. Until now foot-and-mouth vaccination has been applied simultaneously with anti-brucellic vaccination (Baldoni, Renoux), andi-anthrax (Nobili) and vaccination against swine fever and Aujeszky's disease (Lysenko). During the last ten years we have particularly studied the association of anti-foot-and-mouth disease vaccines with anti-brucella and anti-rabies vaccines. We have shown the possiblity of combining these different antigens, either in classical aqueous vaccines in aluminum hydroxide, or in emulsified vaccines containing oily adjuvants. The anti-brucella valences may be agglutinogenic (H 38) or non-agglutinogenic (MacEwen 45/20). The combined vaccines "rabies + foot-and-mouth disease" and "brucellosis + foot-and-mouth disease" can be produced on an industrial scale. For many years millions of animals have been successfully vaccinated in France by means of a combined "rabies + foot-and-mouth disease" vaccine.
联合疫苗被用于多种人类和动物疾病。然而，我们几乎没有含口蹄疫效价的联合疫苗实例，这种联合疫苗能在无需额外处理的情况下方便地对不同疾病进行免疫接种。到目前为止，口蹄疫疫苗一直与抗布鲁氏菌病疫苗（巴尔托尼、勒努）、抗炭疽疫苗（诺比利）以及猪瘟和奥耶斯基氏病疫苗（利先科）同时接种。在过去十年里，我们特别研究了口蹄疫疫苗与抗布鲁氏菌疫苗和抗狂犬病疫苗的联合。我们已经证明，无论是在含氢氧化铝的传统水性疫苗中，还是在含油性佐剂的乳化疫苗中，都有可能将这些不同抗原联合起来。抗布鲁氏菌效价可能是凝集原性的（H 38）或非凝集原性的（麦克尤恩45/20）。“狂犬病+口蹄疫”和“布鲁氏菌病+口蹄疫”联合疫苗可以进行工业化生产。多年来，法国通过“狂犬病+口蹄疫”联合疫苗成功为数百万只动物进行了接种。
