Favre H, Valette L, Précausta P, Roulet C, Brun A, Terré J, Fontaine J, Stellmann C
Dev Biol Stand. 1976;35:409-28.
Medical and sanitary prevention of a growing number of major infectious diseases of bovines has led IFFA-Mérieux to investigate the association of vaccines and to define methods of utilization. Care has been taken to limit the number of interventions and at the same time to retain in the combined valences the efficacy they had when in a state of single constituent. The work which has been carried out for the last ten years, including the study of adjuvants as well as of incompatibility of associations, has permitted the improvement of formulas, reduced in volume (5 ml for a plurivalent dose), in aqueous excipient (aluminum hydroxide and saponin) or oily excipient (oil in water type). These formulas combine 3 foot-and-mouth disease valences with a rabies valence (fixed strain grown on cell culture) or with a brucellosis valence (strain B. abortus MacEwen 45/20 and B. melitensis H 38). The innocuity of these associations allows them to be used in sanitary compaigns; their efficacy is equal to that of monovalent vaccines. A logical vaccination calendar is proposed.
对越来越多的牛的主要传染病进行医学和卫生预防，促使梅里埃公司研究疫苗的联合使用并确定使用方法。已注意限制接种次数，同时在联合效价中保留其单一成分时所具有的效力。过去十年所开展的工作，包括对佐剂以及联合不相容性的研究，已使配方得到改进，剂量体积减小（多价剂量为5毫升），水性赋形剂（氢氧化铝和皂苷）或油性赋形剂（水包油型）。这些配方将3种口蹄疫效价与狂犬病效价（在细胞培养物上生长的固定毒株）或布鲁氏菌病效价（流产布鲁氏菌麦尤恩45/20株和马尔他布鲁氏菌H 38株）相结合。这些联合疫苗的安全性使其可用于卫生运动；其效力与单价疫苗相当。本文提出了一个合理的接种时间表。
