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[用减毒单价或混合疫苗预防动物狂犬病]

[Prevention of animal rabies by an attenuated monovalent or mixed vaccine].

作者信息

Soulebot J P, Précausta P, Brun A, Chappuis G, Terré J, Favre H, Petermann H G

出版信息

Dev Biol Stand. 1978;41:389-99.

PMID:753667
Abstract

In view of the advantages and disadvantages of the different rabies vaccines, classified according to the production method of the virus and according to their nature - activated or inactivated - the choice of an activated vaccine produced on cell cultures is particularly justified for developing countries. The production of this type of vaccine, as well as the methods and results of the activity and innocuity controls are shown in detail. The interest of combined vaccines for certain developing countries, particularly the combined vaccine rabies/foot-and-mouth disease for ruminants, is stressed. The use of this type of vaccine on a vary large scale (more than 20 million doses up to this date) has given complete satisfaction. It should be noted that the same principles have been successfully applied to the realisation of a vaccine for human use, which can be administered before as well as after contamination.

摘要

鉴于不同狂犬病疫苗的优缺点,根据病毒的生产方法以及其性质——活疫苗或灭活疫苗——进行分类,对于发展中国家而言,选择在细胞培养物上生产的活疫苗尤为合理。详细展示了这类疫苗的生产过程以及活性和安全性控制的方法与结果。强调了联合疫苗对某些发展中国家的重要性,特别是反刍动物用的狂犬病/口蹄疫联合疫苗。这类疫苗在非常大规模上的使用(截至目前已超过2000万剂)已带来完全令人满意的效果。应当指出,相同的原则已成功应用于制备人用疫苗,该疫苗在感染前和感染后均可接种。

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