Yajima Misako, Imadome Ken-Ichi, Nakagawa Atsuko, Watanabe Satoru, Terashima Kazuo, Nakamura Hiroyuki, Ito Mamoru, Shimizu Norio, Yamamoto Naoki, Fujiwara Shigeyoshi
Department of Infectious Diseases, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, Japan.
J Infect Dis. 2009 Nov 15;200(10):1611-5. doi: 10.1086/644644.
Humanized NOD/Shi-scid/interleukin-2Rgamma(null) (NOG) mice with full T cell development had significantly longer life span after Epstein-Barr virus (EBV) infection, compared with those with minimal T cell development. Removing CD3(+) or CD8(+) T cells from EBV-infected humanized mice by administration of anti-CD3 or anti-CD8 antibodies reduced their life span. CD8(+) T cells obtained from EBV-infected mice suppressed the outgrowth of autologous B cells isolated from uninfected mice and inoculated with EBV in vitro. These results indicate that humanized NOG mice are capable of T cell-mediated control of EBV infection and imply their usefulness as a tool to evaluate immunotherapeutic and prophylactic strategies for EBV infection.
与T细胞发育极少的人源化NOD/Shi-scid/白细胞介素-2Rγ（缺失）（NOG）小鼠相比，具有完全T细胞发育的人源化NOG小鼠在感染爱泼斯坦-巴尔病毒（EBV）后寿命显著延长。通过给予抗CD3或抗CD8抗体从感染EBV的人源化小鼠中去除CD3(+)或CD8(+) T细胞会缩短它们的寿命。从感染EBV的小鼠中获得的CD8(+) T细胞抑制了从未感染小鼠中分离并在体外接种EBV的自体B细胞的生长。这些结果表明，人源化NOG小鼠能够通过T细胞介导控制EBV感染，并暗示它们作为评估EBV感染免疫治疗和预防策略工具的有用性。
