Tirali Resmiye Ebru, Turan Yeşim, Akal Neşe, Karahan Zeynep Ceren
Department of Pediatric Dentistry, Faculty of Dentistry, University of Gazi, Ankara, Turkey.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Nov;108(5):e117-20. doi: 10.1016/j.tripleo.2009.07.012.
The objective of this study was to test and compare the in vitro effectiveness of sodium hypochlorite (NaOCl), and octenidine hydrochloride (Octenisept) at different concentrations in the elimination of resistant microorganisms including S. aureus, E. faecalis, and C. albicans over a range of time intervals.
A broth dilution test was performed, and the timing for irrigants to kill microbial cells was recorded. Then the samples were compared by using Kruskal-Wallis test, with significance level at P less than .05. Also minimum inhibitory concentration (MIC) of Octenisept was evaluated.
The in vitro antimicrobial effect of the most effective concentrations of the tested irrigants were ranked from strongest to weakest as follows: 100% Octenisept, 50% Octenisept, 5.25 % NaOCl, and 2.5 % NaOCl.
The antimicrobial action is related to type and concentration of the irrigants as well as the microbial susceptibility.
本研究的目的是测试并比较不同浓度的次氯酸钠（NaOCl）和盐酸奥替尼啶（Octenisept）在一系列时间间隔内消除包括金黄色葡萄球菌、粪肠球菌和白色念珠菌在内的耐药微生物的体外有效性。
进行肉汤稀释试验，并记录冲洗剂杀死微生物细胞的时间。然后使用Kruskal-Wallis检验对样本进行比较，显著性水平为P小于0.05。同时评估了Octenisept的最低抑菌浓度（MIC）。
受试冲洗剂最有效浓度的体外抗菌效果从强到弱排序如下：100% Octenisept、50% Octenisept、5.25% NaOCl和2.5% NaOCl。
抗菌作用与冲洗剂的类型和浓度以及微生物敏感性有关。
