Vianna Morgana Eli, Gomes Brenda P F A, Berber Vanessa Bellocchio, Zaia Alexandre Augusto, Ferraz Caio Cezar Randi, de Souza-Filho Francisco José
Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas, SP, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Jan;97(1):79-84. doi: 10.1016/s1079-2104(03)00360-3.
The aim of this study was to investigate in vitro the antimicrobial activity of 0.2%, 1%, and 2% chlorhexidine gluconate (CHX gel and CHX liquid), against endodontic pathogens and compare the results with the ones achieved by 0.5%, 1%, 2.5%, 4%, and 5.25% sodium hypochlorite (NaOCl). A broth dilution test was performed, and the timing for irrigants to kill microbial cells was recorded and statistically analyzed. Both 2.0% gel and liquid formulations eliminated Staphylococcus aureus and Candida albicans in 15 seconds, whereas the gel formulation killed Enterococcus faecalis in 1 minute. All tested irrigants eliminated Porphyromonas endodontalis, Porphyromonas gingivalis, and Prevotella intermedia in 15 seconds. The timing required for 1.0% and 2.0% CHX liquid to eliminate all microorganisms was the same required for 5.25% NaOCl. The antimicrobial action is related to type, concentration, and presentation form of the irrigants as well as the microbial susceptibility.
本研究旨在体外研究0.2%、1%和2%葡萄糖酸氯己定（CHX凝胶和CHX溶液）对牙髓病原菌的抗菌活性，并将结果与0.5%、1%、2.5%、4%和5.25%次氯酸钠（NaOCl）的抗菌活性结果进行比较。进行了肉汤稀释试验，记录了冲洗剂杀灭微生物细胞的时间并进行了统计分析。2.0%的凝胶和溶液制剂在15秒内消除了金黄色葡萄球菌和白色念珠菌，而凝胶制剂在1分钟内杀灭了粪肠球菌。所有测试的冲洗剂在15秒内消除了牙髓卟啉单胞菌、牙龈卟啉单胞菌和中间普氏菌。1.0%和2.0% CHX溶液消除所有微生物所需的时间与5.25% NaOCl所需的时间相同。抗菌作用与冲洗剂的类型、浓度、呈现形式以及微生物易感性有关。
