Institute of Brain Chemistry and Human Nutrition, London Metropolitan University, 166-220 Holloway Road, London N7 8DB, UK.
Prostaglandins Leukot Essent Fatty Acids. 2010 Jan;82(1):51-6. doi: 10.1016/j.plefa.2009.09.002. Epub 2009 Oct 17.
Previous studies suggested that women synthesise docosahexaenoic acid (DHA) more efficiently from their precursors than men. This study investigated the relationship between diet, platelet phospholipids fatty acids and gender. Dietary intake and platelet phosphatidyl-choline (PC) and phosphatidylethanolamine (PE) fatty acids were determined in Caucasian 40 men and 34 women. Absolute and %energy intakes of arachidonic acid (AA), eicosapentaenoic acid (EPA), and DHA, and the ratios of total n-6/n-3 PUFA and linoleic/alpha-linolenic acids did not differ between the sexes. However, women had higher DHA in PC (1.19 vs 1.05 wt%, p<0.05) and PE (3.62 vs 3.21 wt%, p<0.05) than men. Also EPA (1.10 vs 0.93 wt%, p<0.05) was higher in women's PE. Conversely, men had elevated AA and total n-6 fatty acids in PC. The higher platelet DHA levels and lower platelet AA/EPA and AA/DHA ratios in women of child-bearing age compared with men, may lead to less platelet aggregation and vaso-occlusion.
先前的研究表明，女性从其前体中合成二十二碳六烯酸（DHA）的效率比男性更高。本研究调查了饮食、血小板磷脂脂肪酸与性别之间的关系。对 40 名男性和 34 名女性的白种人饮食摄入和血小板磷脂酰胆碱（PC）和磷脂酰乙醇胺（PE）脂肪酸进行了测定。男女之间的必需脂肪酸（AA）、二十碳五烯酸（EPA）和 DHA 的绝对和能量摄入量、总 n-6/n-3 PUFA 和亚油酸/亚麻酸的比例均无差异。然而，女性 PC（1.19 对 1.05wt%，p<0.05）和 PE（3.62 对 3.21wt%，p<0.05）中的 DHA 高于男性。此外，女性的 PE 中 EPA（1.10 对 0.93wt%，p<0.05）也更高。相反，男性 PC 中的 AA 和总 n-6 脂肪酸含量较高。育龄期女性血小板 DHA 水平较高，血小板 AA/EPA 和 AA/DHA 比值较低，可能导致血小板聚集和血管阻塞减少。
