Northern Ireland Regional Medical Physics Agency, Royal Victoria Hospital, Belfast, BT12 6BA, Northern Ireland, UK.
J Neurol. 2010 Apr;257(4):533-9. doi: 10.1007/s00415-009-5356-3. Epub 2009 Oct 22.
Since the basal ganglia are thought to have a role in controlling ocular fixation it is expected that patients with parkinsonian conditions would show impaired performance in fixation tasks. Our study examines ocular fixation in patients with a range of parkinsonian conditions (Idiopathic Parkinson's Disease, Multiple System Atrophy and Progressive Supranuclear Palsy). Eye movements were recorded from 44 patients and 50 age matched control subjects during ocular fixation both with and without a visible target. The data for each patient were then characterised in terms of fixation periods and saccadic intrusions (SI). Patient groups exhibited larger and more frequent SI as well as greater displacement from the fixation target. Patients with Progressive Supranuclear Palsy exhibit larger SI than control subjects when fixation targets are visible, this difference is reversed in the absence of a fixation target. Patients with Multiple System Atrophy show increased frequency of SI both with and without a visible target. Our findings show that ocular fixation is impaired in patients with parkinsonian conditions and may prove useful as part of an oculomotor profile to aid with the differentiation of parkinsonian conditions.
由于基底神经节被认为在控制眼球固视中起作用，因此患有帕金森病的患者在固视任务中表现出受损的表现是可以预期的。我们的研究检查了各种帕金森病患者（特发性帕金森病、多系统萎缩和进行性核上性麻痹）的眼球固视。在有和没有可见目标的情况下，从 44 名患者和 50 名年龄匹配的对照受试者中记录了眼球运动。然后根据固视期和扫视性侵入（SI）对每位患者的数据进行了特征描述。患者组表现出更大和更频繁的 SI 以及更大的从固视目标的位移。当可见固视目标时，患有进行性核上性麻痹的患者比对照组表现出更大的 SI，而在没有固视目标的情况下，这种差异则相反。多发性系统萎缩患者在有和没有可见目标的情况下均表现出 SI 频率增加。我们的发现表明，帕金森病患者的眼球固视受损，这可能有助于作为眼动特征的一部分，以帮助区分帕金森病患者。
