东京葡萄膜炎患者和健康个体中汉赛巴尔通体的血清阳性率。
Seroprevalence of Bartonella henselae in patients with uveitis and healthy individuals in Tokyo.
作者信息
Kamoi Koju, Yoshida Tomoko, Takase Hiroshi, Yokota Mako, Kawaguchi Tatsushi, Mochizuki Manabu
机构信息
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.
出版信息
Jpn J Ophthalmol. 2009 Sep;53(5):490-3. doi: 10.1007/s10384-009-0696-1. Epub 2009 Oct 22.
PURPOSE
To compare the seroprevalence of Bartonella henselae, a pathogen of cat scratch disease, in patients with uveitis and in healthy individuals.
METHODS
Serum samples were collected from 197 consecutive patients with various entities of uveitis at Tokyo Medical and Dental University Hospital, and from 83 healthy age- and sex-matched volunteers. Anti-Bartonella IgG and IgM antibodies were examined by indirect immunofluorescent antibody.
RESULTS
Serum antibodies to B. henselae were positive in 39 of 197 (19.8%) patients with uveitis, and in 21 of 83 (25.3%) of the healthy volunteers. There was no statistical difference in the seroprevalence between the two groups. The overall seroprevalence of B. henselae was 60 of 280 (21.4%).
CONCLUSIONS
The seroprevalence of B. henselae was similar in both patients with uveitis and in healthy volunteers in Tokyo, Japan. These data indicate that a significant number of healthy individuals are asymptomatic carriers of B. henselae, which should be kept in mind when a diagnosis of cat scratch disease is made.
目的
比较葡萄膜炎患者和健康个体中猫抓病病原体汉赛巴尔通体的血清阳性率。
方法
收集东京医科齿科大学医院197例连续的不同类型葡萄膜炎患者以及83例年龄和性别匹配的健康志愿者的血清样本。采用间接免疫荧光抗体法检测抗巴尔通体IgG和IgM抗体。
结果
197例葡萄膜炎患者中有39例（19.8%）血清抗汉赛巴尔通体抗体呈阳性，83例健康志愿者中有21例（25.3%）呈阳性。两组血清阳性率无统计学差异。汉赛巴尔通体总体血清阳性率为280例中的60例（21.4%）。
结论
在日本东京，葡萄膜炎患者和健康志愿者中汉赛巴尔通体的血清阳性率相似。这些数据表明，相当数量的健康个体是汉赛巴尔通体的无症状携带者，在诊断猫抓病时应予以考虑。
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