Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands.
Breast Cancer Res Treat. 2010 Jun;121(2):461-7. doi: 10.1007/s10549-009-0583-y. Epub 2009 Oct 22.
Known risk factors account for about 10-15% of breast cancer incidence suggesting that lifestyle exposures are crucial in its etiology. Previous epidemiological studies on the association between coffee and tea consumption and breast cancer risk have been inconsistent. We investigated the association of coffee and tea consumption with the risk of breast cancer among women in EPIC-NL cohort, a population-based prospective cohort in Netherlands with 27,323 participants. Exposure was measured by a validated food frequency questionnaire, and the outcome was verified by direct linkage with the Netherlands Cancer Registry. A total of 681 invasive primary breast cancers were diagnosed in 9.6 years of follow-up. Coffee intake increased the risk of breast cancer by more than twofold as compared to non-consumers (HR; 2.25, 95% CI; 1.30-3.90). This association did not hold after multivariate adjustment which resulted in a HR of 1.17, 95% CI; 0.65-2.12. After adjustment to breast cancer risk factors and lifestyle, no association was observed between intake of coffee or tea and risk of breast cancer across all categories of intake. These results were also not altered by body mass index (BMI). Coffee and tea consumption does not seem to be related to the risk of breast cancer in women.
已知的风险因素仅占乳腺癌发病率的 10-15%，这表明生活方式的暴露在其发病机制中起着至关重要的作用。先前关于咖啡和茶的摄入与乳腺癌风险之间的流行病学研究结果并不一致。我们在 EPIC-NL 队列中研究了咖啡和茶的摄入与荷兰女性乳腺癌风险之间的关系，该队列是一项基于人群的前瞻性队列，共有 27323 名参与者。通过验证后的食物频率问卷来测量暴露情况，通过与荷兰癌症登记处的直接关联来验证结果。在 9.6 年的随访中，共诊断出 681 例浸润性原发性乳腺癌。与不喝咖啡的女性相比，喝咖啡的女性乳腺癌风险增加了两倍多（HR：2.25，95%CI：1.30-3.90）。在多变量调整后，这种关联不再成立，HR 为 1.17，95%CI：0.65-2.12。在调整乳腺癌风险因素和生活方式后，摄入咖啡或茶与乳腺癌风险之间在所有摄入类别中均无关联。这些结果在调整体重指数（BMI）后也没有改变。咖啡和茶的摄入似乎与女性乳腺癌风险无关。
