Silvera Stephanie A N, Jain Meera, Howe Geoffrey R, Miller Anthony B, Rohan Thomas E
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, NY 10461, USA.
Nutr Cancer. 2007;58(1):22-7. doi: 10.1080/01635580701307945.
There is some evidence from case-control studies that coffee consumption might be positively associated with ovarian cancer risk, whereas the epidemiologic evidence regarding tea consumption and ovarian cancer is inconsistent. To date, there have been few prospective studies of these associations. Therefore, we examined ovarian cancer risk in association with both coffee and tea intake in a prospective cohort study of 49,613 Canadian women enrolled in the National Breast Screening Study (NBSS) who completed a self-administered food frequency questionnaire between 1980 and 1985. Linkages to national mortality and cancer databases yielded data on deaths and cancer incidence, with follow-up ending between 1998 and 2000. Data from the food frequency questionnaire were used to estimate daily intake of coffee and tea. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between categories of coffee and tea intake and ovarian cancer risk. During a mean 16.4 years of follow-up, we observed 264 incident ovarian cancer cases. Tea intake was not associated with ovarian cancer risk in our study population. In contrast, a borderline positive association was observed among women who drank > 4 cups coffee/day compared to women who did not drink coffee (HR = 1.62, 95% CI = 0.95-2.75, P(trend) = 0.06). Given the pervasive use of these beverages, the associations between coffee and tea consumption and ovarian cancer risk warrant investigation in further prospective studies.
病例对照研究有一些证据表明，咖啡消费可能与卵巢癌风险呈正相关，而关于茶消费与卵巢癌的流行病学证据并不一致。迄今为止，很少有关于这些关联的前瞻性研究。因此，我们在一项对49613名加拿大女性进行的前瞻性队列研究中，调查了咖啡和茶摄入量与卵巢癌风险的关联。这些女性参加了国家乳腺筛查研究（NBSS），并于1980年至1985年间完成了一份自行填写的食物频率问卷。与国家死亡率和癌症数据库的关联提供了死亡和癌症发病率数据，随访于1998年至2000年间结束。食物频率问卷的数据用于估计咖啡和茶的每日摄入量。Cox比例风险模型用于估计咖啡和茶摄入量类别与卵巢癌风险之间关联的风险比（HR）和95%置信区间（CI）。在平均16.4年的随访期间，我们观察到264例卵巢癌新发病例。在我们的研究人群中，茶摄入量与卵巢癌风险无关。相比之下，每天饮用超过4杯咖啡的女性与不喝咖啡的女性相比，观察到一种临界正相关（HR = 1.62，95% CI = 0.95 - 2.75，P（趋势）= 0.06）。鉴于这些饮品的广泛消费，咖啡和茶消费与卵巢癌风险之间的关联值得在进一步的前瞻性研究中进行调查。
