Basson M D
Surgical Service, John D. Dingell VA Medical Center, Detroit, MI 48301, USA.
Inflammopharmacology. 2007 Jun;15(3):109-14. doi: 10.1007/s10787-007-1562-8.
The intestinal mucosa is subject to a variety of physical forces in a complex manner during normal gut function and in disease. Intestinal mucosal atrophy during some disease states is a troubling phenomenon that is only partially explained by nutritional parameters. Increasing evidence suggests the possibility that repetitive deformation engendered by peristalsis, villous motility, and interaction with luminal chyme may be trophic for the gut mucosa in normal function, but that the intestinal epithelial response to repetitive deformation may be altered by inflammatory or other states in which plasma or tissue fibronectin levels are increased.
在正常肠道功能和疾病状态下，肠黏膜会以复杂的方式受到多种物理力的作用。某些疾病状态下的肠黏膜萎缩是一个令人困扰的现象，营养参数只能部分解释这一现象。越来越多的证据表明，在正常功能中，由蠕动、绒毛运动以及与肠腔食糜的相互作用所产生的反复变形可能对肠黏膜具有营养作用，但在炎症或其他血浆或组织纤连蛋白水平升高的状态下，肠上皮对反复变形的反应可能会发生改变。
