脂咔唑，来自假泡沫冢菌Acta 1857的具有抗氧化活性的次生代谢产物。

Lipocarbazoles, secondary metabolites from Tsukamurella pseudospumae Acta 1857 with antioxidative activity.

作者信息

Schneider Kathrin, Nachtigall Jonny, Hänchen Anne, Nicholson Graeme, Goodfellow Michael, Süssmuth Roderich D, Fiedler Hans-Peter

机构信息

Institut für Chemie, Technische Universität Berlin, 10623 Berlin, Germany.

出版信息

J Nat Prod. 2009 Oct;72(10):1768-72. doi: 10.1021/np9002178.

DOI:10.1021/np9002178

PMID:19848432

Abstract

A family of new secondary metabolites with a carbazole moiety and an alkyl side chain was isolated from Tsukamurella pseudospumae strain Acta 1857. They were named lipocarbazoles in accordance with their chemical structures, which were determined by mass spectrometry and NMR spectroscopy. Lipocarbazoles are free radical scavengers showing antioxidative activity.

摘要

从假泡温泉放线菌Acta 1857菌株中分离出了一类具有咔唑部分和烷基侧链的新型次生代谢产物。根据通过质谱和核磁共振光谱确定的化学结构，它们被命名为脂咔唑。脂咔唑是具有抗氧化活性的自由基清除剂。