Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity.

作者信息

Hoshino Shotaro, Wakimoto Toshiyuki, Zhang Huiping, Hayashi Fumiaki, Okada Masahiro, Abe Ikuro

机构信息

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan.

出版信息

Bioorg Med Chem Lett. 2015 Sep 15;25(18):3953-5. doi: 10.1016/j.bmcl.2015.07.035. Epub 2015 Jul 18.

DOI:10.1016/j.bmcl.2015.07.035

PMID:26220156

Abstract

Dietziamides A and B, two novel tetramic acid dimers, were isolated from the rare actinomycetes Dietzia timorensis MZ-3 in the course of our HPLC-diode array screening of our collection of terrestrial actinomycetes. The spectroscopic analysis revealed the chemical structures of the first secondary metabolites characterized in the genus Dietzia. Dietziamides A and B showed moderate DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activities.

摘要