纤维细胞：为炎症和纤维化的机制研究带来新的见解。
Fibrocytes: bringing new insights into mechanisms of inflammation and fibrosis.
机构信息
Department of Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA 22908-0466, United States.
出版信息
Int J Biochem Cell Biol. 2010 Apr;42(4):535-42. doi: 10.1016/j.biocel.2009.10.014. Epub 2009 Oct 20.
Abstract
Regeneration and fibrosis are integral parts of the recovery process following tissue injury, and impaired regulation of these mechanisms is a hallmark of many chronic diseases. A population of bone marrow-derived mesenchymal progenitor cells known as fibrocytes, play an important role in tissue remodeling and fibrosis in both physiologic and pathologic settings. In this review we summarize the key concepts regarding the pathophysiology of wound healing and fibrosis, and present data to support the contention that circulating fibrocytes are important in both normal repair process and aberrant healing and fibrotic damage associated with a diverse set of disease states.
摘要
再生和纤维化是组织损伤后恢复过程的组成部分，这些机制的调节受损是许多慢性疾病的标志。一群骨髓来源的间充质祖细胞，称为纤维细胞，在生理和病理环境中都在组织重塑和纤维化中发挥重要作用。在这篇综述中，我们总结了关于创伤愈合和纤维化的病理生理学的关键概念，并提供了数据支持，证明循环纤维细胞在正常修复过程以及与多种疾病状态相关的异常愈合和纤维性损伤中都很重要。
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