循环间充质祖细胞（纤维细胞）在纤维化疾病发病机制中的作用。
The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders.
作者信息
Keeley Ellen C, Mehrad Borna, Strieter Robert M
机构信息
Divisions of Cardiology, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
出版信息
Thromb Haemost. 2009 Apr;101(4):613-8.
Abstract
Fibrocytes are bone marrow-derived mesenchymal progenitor cells that express markers of leukocytes, haematopoietic progenitor cells, and fibroblasts. They play a pivotal role in tissue remodelling and fibrosis in both physiologic and pathologic settings. Fibrocytes are unique in that they are capable of differentiating into fibroblasts and myofibroblasts, as well as adipocytes. In this review we will present data supporting the critical role they play in the pathogenesis of chronic inflammatory fibrotic diseases of the lungs, heart and vasculature.
摘要
纤维细胞是源自骨髓的间充质祖细胞，表达白细胞、造血祖细胞和成纤维细胞的标志物。它们在生理和病理环境下的组织重塑和纤维化过程中发挥着关键作用。纤维细胞的独特之处在于它们能够分化为成纤维细胞、肌成纤维细胞以及脂肪细胞。在本综述中，我们将展示支持它们在肺部、心脏和血管慢性炎症性纤维化疾病发病机制中所起关键作用的数据。
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