Thomas Vinai Chittezham, Hancock Lynn E
Division of Biology, Kansas State University, Manhattan, Kansas 66506, USA.
Int J Artif Organs. 2009 Sep;32(9):537-44. doi: 10.1177/039139880903200902.
Bacterial autolysis has recently been identified as a key mechanism that regulates different phases of biofilm development including microcolony formation and dispersal. However such autolytic measures are limited to a subfraction of cells within the entire biofilm population. Here we speculate on the role biofilm heterogeneity plays in limiting autolysis within biofilms and further describe the molecular regulation of suicidal and fratricidal mechanisms in biofilm development of Staphylococcus aureus and Enterococcus faecalis.
细菌自溶最近被确定为一种关键机制，它调节生物膜形成的不同阶段，包括微菌落的形成和分散。然而，这种自溶作用仅限于整个生物膜群体中的一部分细胞。在此，我们推测生物膜异质性在限制生物膜内自溶中所起的作用，并进一步描述金黄色葡萄球菌和粪肠球菌生物膜形成过程中自杀和杀同种机制的分子调控。
